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Human Leukocyte Antigen-Adverse Drug Reaction (HLADR) is an open and freely accessible database which provides dedicated information for associations between Human Leukocyte Antigens (HLA) and Adverse Drug Reactions (ADR). This database currently consists of more than 1,700 records (i.e., drug-HLA pairs associated with ADRs) involving more than 50 FDA-approved drugs, 450 HLA alleles and 30 kinds of related ADRs from published literatures. Each database entry is a 2 by 2 contingency table on which performance metrics (such as p value, odds ratio, sensitivity, specificity, positive predictive value, and negative predictive value) were calculated in a consistent manner for different drug-HLA pairs. Therefore, the results from multiple studies could be compared in terms of different performance perspectives for a given HLA allele to serve as a safety biomarker against an ADR induced by the drug. [...]

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