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HLADR is a database for associations between HLA and Adverse Drug Reaction (ADR). Currently we have collected more than 600 HLA-ADR correlations in existing reported articles and provide both interface and downloadable data for users. Each correlation is stored as an entry in our database. For each entry, the HLA allele explored in the case-control study, the related drug and corresponding Adverse Drug Reaction (ADR) are provided along with the case-control study data. With the help of this database, researchers can find potential ADR related HLA alleles for further research and doctors can re-evaluate the drug therapy to promote personalized medicine.

Database/search result summary

To browse the HLADR database, please click the Browse link at the left side menu. The first screen you will see is the database summary (if you are just browsing) or the search result summary (if you searched something). Here is an example. If you search "Abacavir" in the "Drug" column, you will get the result in the following picture.

In this picture, our server found 55 related entries according to this query and provided a comprehensive summary about all the search results. Among all the search results, it identified 1 unique drug, 13 unique HLA alleles, and 1 unique Adverse Drug Reaction (ADR). The only one unique drug, abacavir, which had all the 55 corresponding entries, was given. Among the 13 unique HLA alleles, the top 5 HLA alleles were displayed and ranked by their corresponding entry number. The HLA allele B*57:01 was ranked to the top by 31 entries. The only one Adverse Drug Reaction (ADR), hypersensitivity syndrome, was found to cover all 55 entries as well. You can click the links on the summarized items to search and summarize them in our database (when the links are displayed), or you can click on the Drugbank, IMGT/HLA or PharmGKB icon to search them on other websites. In the following search box, you can choose a column, Drug, HLA, or ADR to search in, and then type a word in the input box and click Go button to see your result.

Browse HLADR entry list

Below the summary section, you will see a list of HLA-ADR correlations. You can click on any of these table header to rank the results. The arrow showing in the following picture indicates this result is ranked by 'Drug' column in ascending order.

An 'NA' in any column indicates the corresponding value is not available. Click on either FD link at the left side or the View icon on the right to see the detail information of the entry. Click on the links in the Drug/HLA/ADR column will search the keyword you clicked in our database. The icons after these links will lead you to other related sites such as Drugbank, IMGT/HLA and PharmGKB.

HLADR page part 1: basic information

Click on the FD link at the left side or the View icon on the right to see the detail information of the entry. We take entry FD1 as an example. Here is the first part of an entry.

HLADR page part 2: the contingency table

The contingency table and its corresponding values

  Number for case group (subjects having adverse drug reaction) Number for control group (subjects tolerant to the corresponding drug) Total
HLA+ (HLA allele positive) Number of case HLA+ Number of control HLA+ Number of HLA+
HLA- (HLA allele negative) Number of case HLA- Number of control HLA- Number of HLA-
Total number Total number for case group Total number for tolerant/health control group Number of subjects involved in analysis (Number of total subjects - Number of subjects excluded)

If there is no available information, the corresponding values will show "NA" (not available). If the HLA allele positive or negative number in the case or control group is not given in its original article, we will deduce the corresponding values according to other information such as the values of sensitivity and specificity. Here is an example for FD11.

HLADR page part 3: variables for association evaluation

Associations between HLA alleles and adverse drug reactions can be evaluated by the following variables in the table.

The values in the parentheses or marked up with a star (*) are calculated by us as a reference. The corresponding value may not exist in the original paper, or the value calculated by us may be different from the original value. An 'NA' in any column indicates the corresponding value is not available.

Links to related websites